Ultra-High Performance on any HPLC

Phenomenex, Inc introduces Kinetex - ultra-high performance LC columns based on the company’s new core-shell silica technology.

Kinetex meets researchers’ need to improve results and increase productivity without large capital expenditures. By delivering significant improvements in speed and separation efficiency over traditional 3- and 5-micron columns, Kinetex enables chromatographers to get performance comparable to sub-2-micron columns without investing in UHPLC systems. With Kinetex, researchers can achieve UHPLC results on any LC instrument platform, and any chromatographic method can now be completed at a fraction of the time previously required, without sacrificing performance. The increased separation efficiencies of Kinetex also significantly reduce solvent usage and maintain long column life.

With traditional, fully porous particles, efficiency decreases as flow rate increases, resulting in loss of resolution and sensitivity, which slow the overall analysis time. Kinetex core-shell technology enables high resolution and sensitivity over an extended linear velocity without generating excessive backpressure. These columns provide roughly twice the efficiency of fully porous 3-micron columns and three times the efficiency of fully porous 5-micron columns with significantly lower limits of detection and quantitation.

Initially, Kinetex core-shell columns are available in two particle sizes – 2.6- and 1.7- micron – and three chemistries – C18, PFP and HILIC. Kinetex 2.6-micron columns deliver separation efficiencies that match or exceed the performance of traditional fully porous sub-2-micron columns. The Kinetex 1.7-micron is the first ever sub-2-micron core-shell technology and delivers efficiency gains of 15 to 20% over traditional fully porous sub-2-micron columns.

Method transfer challenges, common with traditional sub-2-micron products, are eliminated with Kinetex. Methods developed with either 2.6- or 1.7-micron Kinetex columns are scalable and can be transferred to any LC system using the 2.6-micron column, regardless of the instrument’s pressure capability.