Breakthrough Performance in Differential Ion Mobility Spectrometry

AB Sciex announced the introduction of AB Sciex SelexION™ Technology, the first differential ion mobility separation technology to deliver a new level of selectivity that is based on the shape of the molecule. Current approaches to optimising selectivity are limited to the fragmentation patterns of the individual compounds and chromatographic conditions. Often, these parameters do not provide enough selectivity to eliminate or separate isobaric interferences, or to reduce high background noise in complex samples. To solve this challenge, AB Sciex developed the SelexION™ Technology, which significantly improves selectivity and performance for any application requiring the separation of isobaric species, isolation of challenging co-eluting contaminants and elimination of high background noise.

The SelexION™ Technology is well suited for assays with contaminants that are difficult to separate, such as in the pharmaceutical, contract research, food safety, environmental testing and therapeutic drug monitoring industries. These assays commonly require a fast, reproducible and easy to use approach to enhance the selectivity of LC/MS/MS separations without compromising sensitivity.

This new DMS technology improves data quality and accelerates sample preparation procedures. It possesses day-to-day reproducibility, robustness and ease of use, while delivering an additional dimension of selectivity for sensitive quantitative and qualitative analyses, within a UHPLC time scale and over multiple MRMs (multiple reaction monitoring).

DMS technology works with the following industry-leading mass spectrometers: AB Sciex TripleQuad™ 5500 System and AB Sciex QTRAP® 5500 System. The AB Sciex Triple Quad 5500 System delivers the most accurate quantitative results at the industry’s fastest scan speeds to identify the greatest number of target analytes at the lowest concentrations in complex samples. The AB Sciex QTRAP 5500 System is a unique, next-generation mass spectrometer that integrates triple quadrupole capabilities with linear ion trap technology called Linear Accelerator™ Trap. This combination results in the only system on the market that seamlessly integrates industry-leading sensitivity and multiple dimensions of selectivity for both quantitative and qualitative analysis.