Mass Spectrometry & Spectroscopy

  • Can a Pill Replace Insulin Injections?

Can a Pill Replace Insulin Injections?

Mar 16 2019 Read 1260 Times

Injections can be a source of anxiety, fear and pain for so many people. But if you’re a diabetic, there is simply no other way of getting the necessary insulin. Until now. Giovanni Traverso, an assistant professor at Harvard Medical School, and his team have developed a “needle pill” that could replace daily insulin injections for diabetics as part of a new study.

The “needle pill”

The device comes in the form of a pea-sized capsule, containing a small needle of solid, compressed insulin. The needle is attached to a retracted spring, held in place by a disk of sugar. Upon ingestion into the stomach, the sugar dissolves and the spring releases the needle into the stomach wall.

The study showed that the metal spring and the remaining capsule was able to be passed through the system, without causing any apparent problems.

The pill’s shape is inspired by the leopard tortoise, which has a rather steep, domed shell, allowing it to correct itself in case it rolls onto its back. The capsule takes inspiration from the shell in that its domed shape allows the needle to continuously reorientate itself, so it is facing the stomach wall.

After extensive testing on pigs, the new pill was found to have worked consistently and deliver enough insulin to meet the needs of someone with diabetes. In the initial testing on pigs, researchers were able to deliver around five milligrams of insulin, which is comparable with the daily amount needed by someone with type 2 diabetes.

Taking the pain out of injections

Traverso and hist team say the study was inspired by a need for an injection alternative. “Our motivation is to make it easier for patients to take medication, particularly medications that require an injection. The classic one in insulin, but there are many others.”, he explains. Unlike the skin, the stomach wall does not have pain receptors, so the “needle pill” is unlikely to be uncomfortable or painful for the patient.

To find out more about efforts to improve patient care, take a look at the article ‘Fighting the Resistance: How Rapid Microbial ID with MALDI MS and Antimicrobial Susceptibility Testing Improves Patient Care’.

Moving forward, researchers are continuing to test the insulin on pigs and dogs, which doesn’t cause them any harm, and hope to start human trials within the next three years. Insulin injections are just one of the painful daily chores that Traverso and his team hope to ease with their pain-free alternative.

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment

Digital Edition

Lab Asia December 2020

December 2020

In This Edition Articles - The Movement Towards More Comprehensive Testing of Mycotoxins in Cannabis - Addressing proper HACCP implementation - Micropatterning: The art of micro-controlling...

View all digital editions



Dec 08 2020 Beijing, China


Dec 08 2020 VIrtual event

Nano Tech 2021 - NEW DATES

Dec 09 2020 Tokyo, Japan

Medical Fair Asia 2020 - NEW DATES

Dec 09 2020 Virtual event

View all events