Mass Spectrometry & Spectroscopy
Differential Ion Mobility Interface Boosts Proteomics Workflow Performance
Aug 28 2018 Read 786 Times
When integrated with a high-resolution mass spectrometer, the Thermo Scientific FAIMS Pro interface is designed to increase the breadth and depth of proteins scientists can identify while reducing time-consuming sample preparation steps.
"Scientists increasingly demand improved protein coverage during proteomic experiments; increased dynamic range to comprehensively characterise and validate proteins and their post-translational modifications; and more accurate quantitation of hundreds to thousands of proteins in a single run in shorter analysis times," said Iain Mylchreest, Vice President, R&D, Analytical Instruments, Thermo Fisher. "Building on last year’s enhancements to the industry-leading Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer, the FAIMS Pro interface provides new analytical performance that is expected to reduce sample and spectral complexity, improve selectivity and increase coverage of the proteome."
"We have been extremely impressed with the performance of the Thermo FAIMS device for shotgun proteomics," said Josh Coon, Thomas and Margaret Pyle chair at the Morgridge Institute for Research, Professor of Biomolecular Chemistry and Chemistry at the University of Wisconsin, Madison, and director of NIH National Center for Quantitative Biology of Complex Systems. "FAIMS enables considerably more sample depth per unit time and could eliminate the need for pre-fractionation of peptides for most applications."
The FAIMS Pro interface is designed to improve analytical performance compared to existing interface options by: providing faster, higher-quality results through its next-generation design, further enhancing instrument selectivity and detection limits through gas phase fractionation and reduced matrix interference; leveraging menu-driven software to design methods using pre-configured parameters, increasing productivity and simplifying use; reducing sample fractionation steps, which can help save time, long-term costs and maintenance through increased productivity; achieving high data quality on sample-limited studies through an interface exclusively designed to improve nano, capillary and microflow applications.
When the interface is combined with the Thermo Scientific Orbitrap Fusion Lumos Tribrid or Thermo Scientific Orbitrap Fusion Tribrid high-resolution mass spectrometers, laboratories have a comprehensive solution to improve selectivity and ensure increased productivity across a range of proteomics workflows.
For more information on the Thermo Scientific FAIMS Pro interface, please click here.
Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.
In This Edition Mass Spectrometry & Spectroscopy - 67th ASMS Conference on Mass Spectrometry and Allied Topics - Modular MS Bench System with Integrated Gas Supply for Sciex LC-MS/MS Unveile...
View all digital editions
Aug 04 2019 Anaheim, CA, USA
Aug 04 2019 Portland, OR, USA
Aug 05 2019 Lombard, IL, USA
Aug 25 2019 San Diego, CA, USA
Sep 01 2019 Berlin, Germany