Microscopy & Microtechniques

  • System Helps Scientists Study the Effects of Changes in Humidity in the Development of new APIs

System Helps Scientists Study the Effects of Changes in Humidity in the Development of new APIs

Apr 19 2018 Read 1896 Times

Dr James McCabe is an Associate Principal Scientist in the Early Product Development Group (EPD) of Astra Zeneca based in Macclesfield in the UK. His research aim is to find the optimal solid form of an active pharmaceutical ingredient (API) for drug development and understand the risks and opportunities associated with that solid form. To this end, Dr McCabe is always looking for optimum instrumentation to provide the maximum amount of data.

Talking about his experience in using humidity controllers and how he settled on the use of the RH95 system from Linkam, Dr McCabe said: “I have used many humidity systems including dynamic vapour sorption (DVS) from various vendors as well as using them when making environmental X-ray powder diffraction measurements. The advantage of the Linkam RH95 humidity system used in conjunction with one of their temperature stages (THMS600) is that visual changes in crystal/particle morphology (size, shape etc.) can be observed in real time. The stage provides the added ability of then dehydrating samples via elevated temperature as part of the same experiment. This capability is also available on DVS systems, but the images are then macro as opposed to micro. An additional advantage is that in principle a single crystal of material could be assessed using the Linkam humidity system, a sample amount too small for other techniques.”

Dr McCabe's work with optical temperature stages has included the use of a new technique called TASC – Thermal Analysis by Structural Characterisation. TASC provides spatially resolved information on thermal transitions to images/movies acquired by temperature stage microscopy. It highlights any structural changes in the sample providing excellent complementary information with traditional forms of differential and modulated differential scanning calorimetry, DSC & MDSC, both being macro techniques.

Dr McCabe is optimistic for future exploitation of TASC in the pharmaceutical industry. “TASC appears to be a powerful thermo-optical technique for measuring optical changes within a sample. Glass transition and melting temperatures can quickly be measured, and complex mixed-phase systems can be assessed. I will carry out further work to apply this technique to other areas such as crystal growth (induction times), dissolution and physical stability of amorphous materials when exposed to the combination of both temperature and humidity change.”

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment




Digital Edition

Lab Asia August 2019

August 2019

In this Issue Articles Mass Spectrometry & Spectroscopy 67th ASMS Conference on Mass Spectrometry and Allied Topics Chromatography Using Gas Chromatography for measuring atmo...

View all digital editions

Events

ACS National Meeting & Expo, Fall 2019

Aug 25 2019 San Diego, CA, USA

Microscopy Conference 2019

Sep 01 2019 Berlin, Germany

BMSS Annual Meeting

Sep 03 2019 Manchester, UK

JASIS 2019

Sep 04 2019 Chiba City, Japan

ICMGP 2019

Sep 08 2019 Krakow, Poland

View all events