Protein causes damage after heart attack

Scientists have discovered the reason why some heart attacks lead to such significant heart damage, including rupture.

In a study published by journal Nature Medicine and undertaken by researchers from the University of Iowa, it was noted that many people who survive a heart attack initially die in the days that follow as a result of cardiac rupture, which is when the heart wall bursts.

However, the scientists have now identified a single protein, known as CaM kinase, which could be responsible for the biochemical reaction that triggers the cardiac rupture.

They found that after a heart attack, the body produces a wide range of chemicals to prevent further failure and work towards healing and repair, however this reaction can end up causing further problems.

"Two of the medicines that are most effective for heart failure are beta-blockers, which block the action of adrenaline, and drugs that block the angiotensin receptor," said Dr Mark E Anderson, head of internal medicine and senior study author. "The third tier of therapy is medication that blocks the action of aldosterone."

He added that aldosterone may be able to block CaM kinase.

Posted by Ben Evans