News & Views

  • CEM Reveals Common Herpes Virus Structure

CEM Reveals Common Herpes Virus Structure

Aug 19 2018 Read 1199 Times

Researchers at the MRC-University of Glasgow Centre for Virus Research have used Nobel Prize- winning cryo-electron microscopy to obtain high resolution images of the biological mechanisms used by the common herpes virus to infect people. The researchers hope that these findings could lead to the development of new drugs to treat illnesses caused by the virus which include both cold-sores and chicken pox. Members of this family of viruses can also cause cancers and severe illnesses in unborn children.

However, at only 1/10,000th of a millimetre in diameter, the protective capsid, (shell) where the herpes virus stores DNA which will be used to infect its host, has until now been difficult for scientists to analyse.

Cryo-electron microscopy enabled the scientists to reveal the structure of a motor-like assembly called a portal. Herpes viruses pump their DNA into preassembled capsids through the portal. When a herpes virus infects our cells, the DNA is ejected from the capsid by the same portal machinery.

Study lead author Dr David Bhella, from the MRC-University of Glasgow Centre for Virus Research, said: “Cryo-electron microscopy, combined with new computational image processing methods allowed us to reveal the detailed structure of the unique machinery by which the virus packs DNA into the capsid. The DNA is packed very tightly, reaching a pressure similar to that inside a bottle of Champagne.”

Dr Richard Henderson at the MRC Laboratory of Molecular Biology was awarded the 2017 Nobel Prize in Chemistry alongside Professor Jacques Dubochet and Dr Joachim Frank for developing cryo-EM for the high-resolution structure determination of biomolecules in solution.

Dr Jonathan Pearce, Head of Infections and Immunity at the MRC, said: “Dr Bhella and his team have now used this technique to elucidate the structure of the herpes virus, revealing a ‘molecular machine’ that is involved in virus replication. The findings provide scientists with a better understanding of the virus and its anatomy, and, in turn, an insight into potential new therapeutic targets.

“These elegant experiments exemplify the potential of the Scottish Centre for Macromolecular Imaging due to be launched later this year at the CVR, which will support vital research into diseases posing the greatest threat to human health.”

The study, ‘Structure of the herpes-simplex virus portal-vertex’ is published in PLOS Biology. The work was funded by the MRC.

Read comments0

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Digital Edition

Lab Asia February 2019

February 2019

In this edition Articles - Detection of molecular markers in aquatic sediments by ion profi les obtained by GC/MS system - Fighting the Resistance: How Rapid Microbial ID with MALDI MS and A...

View all digital editions


Biotech World

Feb 25 2019 Moscow, Russia

China Lab 2019

Feb 26 2019 Guangzhou, China

SmartLab Exchange

Feb 27 2019 Berlin, Germany

IFPAC Annual Meeting

Mar 03 2019 Maryland, (Washington DC), USA

Forensics Europe Expo

Mar 05 2019 London, UK

View all events