Sign up now
Maximising Core-Shell Performance on Conventional HPLC Systems

Chromatography

Maximising Core-Shell Performance on Conventional HPLC Systems

09 Jul, 2012

Published over 14 years ago. See the latest and most current information on Chromatography.

Jeff Layne and Simon Lomas
1 min read
Share on Facebook Share on LinkedIn Share on Twitter / X Share via Email
Download

In order to fully realise the performance potential of core-shell columns on conventional HPLC systems, some simple system optimisations maybe necessary to minimise extra-column band broadening effects. In this report, a series of simple measures (adjusting detector acquisition rate; optimising connective tubing; use of a low-volume flow cell) are made to a standard HPLC system in order to achieve UHPLC-comparable performance with sub-3μm core-shell media.

Latest Articles

From VOCs to pesticide residues: how GC 2000 tackles complex GC applications

Chromatography

From VOCs to pesticide residues: how GC 2000 ta...

3 min read

For laboratories analysing trace-level, multi-component analytes in complex samples, selecting a...
Enhancing evaporation efficiency: the impact of temperature and gas flow on blowdown evaporation

Chromatography

Enhancing evaporation efficiency: the impact of...

12 min read

Evaporation is an endothermic process undergone by all liquids. This physical state change occurs...
Optimising the performance of peristaltic pumps by using data from a high-resolution liquid flow meter

Chromatography

Optimising the performance of peristaltic pumps...

7 min read

This work highlights how modern devices for continuous monitoring of liquid flow rates helps labo...
Advancements in predicting separations of volatiles in Gas Chromatography Applications by using free available internet tools saving a lot of development time

Chromatography

Advancements in predicting separations of volat...

4 min read

For many methods existing/proven methods are on the books. Many applications you can find at the...
Why high-purity chromatography solvents matter more than ever

Chromatography

Why high-purity chromatography solvents matter...

4 min read

At its core, chromatography is built on detecting very small differences by separating, identifyi...
From separation to insight: How next-generation analytical platforms are reshaping laboratory science

Chromatography

From separation to insight: How next-generation...

9 min read

Analytical science is undergoing a quiet but profound transformation. Across environmental monito...
The Significance of Monitoring Impurities in GLP-1 drugs

Chromatography

The Significance of Monitoring Impurities in GL...

6 min read

Glucagon-like peptide-1 (GLP-1) receptor agonists, such as liraglutide, semaglutide, exenatide, a...
Analysis of Anions and Oxoanions using Ion Chromatography Mass Spectrometry (IC-MS)

Chromatography

Analysis of Anions and Oxoanions using Ion Chro...

5 min read

Ion Chromatography Mass Spectrometry (IC-MS) is a powerful tool to handle many challenging analyt...
Vacuum ultraviolet detection: Redefining chromatographic analysis in GC and LC

Chromatography

Vacuum ultraviolet detection: Redefining chroma...

7 min read

Chromatographic techniques underpin analytical workflows across pharmaceutical development, chemi...

Related Articles

Laboratory products

The Significance of Monitoring Impurities in GLP-1 drugs
The Significance of Monitoring Impuri...
Arrow

Chromatography

New Concerns about PFAS in Food: The Convergence of Environmental Contamination and Food Safety
New Concerns about PFAS in Food: The...
Arrow

Chromatography

The Movement Towards More Comprehensive Testing of Mycotoxins in Cannabis
The Movement Towards More Comprehensi...
Arrow

Chromatography

Increased Sensitivity, Improved Resolution and Faster Analysis Times For Compendial Methods
Increased Sensitivity, Improved Resol...
Arrow

ILM 51.6 Sept 2026

Explore our Digital Edition

Discover the latest news and research

Digital edition
View all digital editions Arrow

Explore Our Other Sites

Envirotech Online
EPA rescinds guidance states used to address PFAS in wastewater discharge permits
Explore more Arrow
Pollution Solutions Online
Smarter wastewater management helps futureproof distillery operations and protect local watercourses
Explore more Arrow
Petro Online
CSB finds no gas monitors were issued before fatal hydrogen sulphide release during decommissioning
Explore more Arrow
Chromatography Today
New low-shear pump enhances cell performance and productivity
Explore more Arrow