High Confidence Analysis of Complex Samples

Agilent Technologies, Inc introduced the Agilent 6540 Ultra- High-Definition (UHD) Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) liquid chromatography/mass spectrometry (LC/MS) system at the 2009 ASMS conference. This benchtop system offers superior data quality and advanced analytical capabilities, enabling researchers to profile, identify, characterise and quantify low molecular-weight compounds and biomolecules with greater confidence.

The Agilent 6540 Q-TOF is by far the highest-performing benchtop Q-TOF on the market, delivering much better performance than comparable Q-TOF products without the inherent trade-offs in speed, dynamic range, isotopic fidelity and mass range that are required by orbitrap-based systems. Innovative Ion Beam Compression (IBC) and Enhanced Mirror Technology (EMT) produce ultra-high-definition mass accuracy and mass resolution while maintaining a benchtop format.

"While others have pursued a ’bigger must be better’ approach to TOF flight tube development, Agilent has used advanced engineering to dramatically improve performance and maintain a benchtop-instrument format," said Ken Miller, Agilent Senior Global Marketing Director for LC/MS. "We’ve achieved huge gains in mass accuracy and resolution while maintaining our industry-leading sensitivity and dynamic range. And the system can

run fast to generate accurate mass MS and MS/MS data for UHPLC analyses without the resolution loss suffered by orbitraps. This is the perfect system for state-of-the-art qualitative analysis in support of proteomic, metabolomic or non-targeted food safety and environmental studies."

The new 6540 UHD Q-TOF delivers industry-leading performance in the most important categories and also offers applicationspecific software packages to take full advantage of this exceptional data quality to improve results from proteomics, metabolomics and common screening applications.