Anachem believe exhaustive drug solubility screening early in the development process has become an important focus for pharmaceutical scientists. Low solubility can hamper a drug's bioavailability and make ADME assays more difficult. Solubility assays are also vital for development scientists who need to select amongst salt or crystalline forms, evaluate formulation excipients and determine minimum absorbable dose. The unique new ReactArray? ST Automated Equilibrium Solubility Testing Workstation now enables faster, more convenient and efficient gathering of this critical data under completely controlled conditions.
ReactArray ST, based on the proven ReactArray 215SW platform is fitted with a ten position Reactivate rack with individual temperature (-30oC to 150 oC) and stirring control. A new design study vessel (patent applied for) includes a spring loaded filter. During sampling, the workstation probe presses the test device down into the slurry at equilibrium; the probe is then able to take a quantitative filtered sample for subsequent HPLC analysis. The test device has been shown to deliver excellent data across a wide range of solvents and temperatures.
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