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  • Achieving the Critical Formulation Temperature in Freeze-drying

Achieving the Critical Formulation Temperature in Freeze-drying

Nov 24 2008 Read 4688 Times

Every formulation has a critical temperature, below which it should be cooled for complete solidification and maintained below during primary drying in order to prevent processing defects.

In R&D, the glass transition temperature of the maximally freeze concentrated solute (Tg`) is often used as the critical temperature, although Tg` and the collapse temperature (Tc) are frequently reported to show a bias of 1-5 degrees C for the same formulation.
An informative new presentation ( is available from Genevac that provides you with the best ways to achieve the critical formulation temperature in order to develop an optimised freeze-drying process.

Please follow the
link to download the presentation

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