• New Multi-species Kit for Toxicokinetic Studies introduced

Laboratory Products

New Multi-species Kit for Toxicokinetic Studies introduced

Mar 27 2018

Gyros Protein Technologies AB has announced it has introduced a new reagent kit for early-stage biotherapeutic toxicokinetic (TK) studies.

The new Gyrolab® Generic TK Kit adds to a growing menu of ready-to-use kits, and allows researchers to more efficiently quantify human therapeutic antibodies (IgG) in automated, nanoliter-scale Gyrolab xP and Gyrolab xPlore™ systems. The Gyrolab Generic TK kit complements the Gyrolab Generic Pharmacokinetic (PK) Kit, introduced earlier in 2017, which is based on the same reagents. The TK Kit addresses a higher concentration range compared to the PK Kit, making it more suited to toxicokinetic studies. Together the kits more fully meet the needs of Gyrolab system users performing PK/TK assays in preclinical and clinical studies.

The kits eliminate the need for assay development, as they are supplied in a ready-to-use format, and enable increased productivity as results are generated in just 70 minutes. The two kits cover a combined range of 5 logs, minimising dilution steps and repeats when performing human IgG quantification in early biotherapeutic development. The kits are designed for use with several species of preclinical animal models, including mouse and cynomolgus monkey.

Jasmine Gruia-Gray, SVP Marketing, Gyros Protein Technologies, commented: “In time-critical workflows within the biotherapeutics industry, Gyrolab systems are increasingly becoming recognised as the gold standard for immunoassays. The new Gyrolab Generic TK Kit, alongside the PK Kit, reduces risk of errors associated with the manual steps of other methods, and helps to maximise productivity across a wide IgG concentration range.”

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