Collaboration to Deepen Understanding of Molecular Complexes

Thermo Fisher Scientific and the National Institute for Bioprocessing Research and Training (NIBRT) have formed a collaboration focused on the development of analytical solutions for the characterisation of complex biopharmaceuticals.

Biopharmaceuticals represent protein molecules produced by genetically engineered living cells using large scale industrial bioprocessing and advanced analytical characterisation is required for the end product to maintain high quality levels. NIBRT will

Under the agreement NIBRT will develop workflows using Thermo Scientific technology including the company’s biomolecule columns and associated consumables, liquid chromatography systems and Orbitrap high resolution mass spectrometers.  

“This collaboration is important because it enables our team to access Thermo Fisher’s world leading columns and analytical instrumentation to develop total analytical solutions and streamline the characterisation of complex biopharmaceuticals,” said Dr. Jonathan Bones, principal investigator, NIBRT’s Characterisation and Compatibility Laboratory.  “The availability of total analytical solutions to scientists across the world is empowering and motivates us at NIBRT to continually perform excellent impactful research.”

Jakob Gudbrand, president of chromatography and analytical technologies at Thermo Fisher commented: “NIBRT is an independent centre of excellence with collaborations across the major biopharmaceutical companies in the industry.  This allows them to provide valuable insights to improve the technology, simplify analysis, generate informative characterisation data and understand these complex molecules -- ultimately enabling scientists to move from sample to knowledge quickly and efficiently.”

NIBRT’s workflows and methods will be uploaded to the Thermo Scientific AppsLab library, enabling scientists across the globe to access and download these total analytical solutions directly to their instrument. 

“We are delighted to be working with Thermo Fisher,” said Dominic Carolan, CEO, NIBRT. “World class collaborations such as this are testament to Ireland’s emergence as a global centre of excellence in all aspects of biopharmaceutical manufacturing.”