The escalating need for impurity analysis in
pharmaceuticals provides the basis for
evaluating fast, simple, and reliable methods of
analysis. UPLC provides the speed and resolving
power to develop rapid separation methods. A
new breed of fast scanning quadrupole MS
instruments are robust, reliable, easy-to-use,
moderately priced, and well matched to the
demand for measuring the narrow UPLC peaks
in real-time but traditionally have not been
considered as tools for reliable formula ID. By
combining these systems with a new
calibration available through MassWorks?
CLIPS formula search, these systems can now
become reliable workhorse systems for
impurity determination.
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