Rapid Genetic Testing for Warfarin Dosing on an ESE-Quant TS Reader An Example for Future Point-of-Care Solutions to Personalised Medicine

Improved speed and accuracy of medical assessment tools combined with reduced cost and easy operation are important factors in Point-of-Care testing. In the future such tests should be carried out directly at the physician’s office or even at home by

patients monitoring their health conditions. Therefore portable test systems working directly from crude samples will render obsolete the need for sending specimen to clinical laboratories. Enabling the physician to assess a medical condition on-site will

greatly reduce pressures time in patient treatment, and lead to significant saving in health care cost. As an example when prescribing Warfarin at first, the metabolic compatibility of the patient should be assessed to avoid risk of adverse side effects.

Here we report a fully isothermal on-site genetic test system for Warfarin dosing, which works directly from crude blood samples without the necessity of timeconsuming sample purification steps. Using an easy to use ESE-Quant TS reader fully

interpreted results are obtained within less than 60 minutes by simply pushing one button. The underlying DNA based SmartAmp 2 nucleic acid detection technology is highly specific and its affordability makes it an ideal candidate to be deployed in every physician’s office and research laboratories.