Laboratory Products
Rapid Genetic Testing for Warfarin Dosing on an ESE-Quant TS Reader An Example for Future Point-of-Care Solutions to Personalised Medicine
Jan 27 2010
Author: Alexander Lezhava, Sylvia Victor, Toshihiza Ishikawa, Yoshihide Hayashizaki RIKEN, Klaus Haberstroh and Konrad Faulstich on behalf of Unassigned Independent Article
Improved speed and accuracy of medical assessment tools combined with reduced cost and easy operation are important factors in Point-of-Care testing. In the future such tests should be carried out directly at the physician’s office or even at home by
patients monitoring their health conditions. Therefore portable test systems working directly from crude samples will render obsolete the need for sending specimen to clinical laboratories. Enabling the physician to assess a medical condition on-site will
greatly reduce pressures time in patient treatment, and lead to significant saving in health care cost. As an example when prescribing Warfarin at first, the metabolic compatibility of the patient should be assessed to avoid risk of adverse side effects.
Here we report a fully isothermal on-site genetic test system for Warfarin dosing, which works directly from crude blood samples without the necessity of timeconsuming sample purification steps. Using an easy to use ESE-Quant TS reader fully
interpreted results are obtained within less than 60 minutes by simply pushing one button. The underlying DNA based SmartAmp 2 nucleic acid detection technology is highly specific and its affordability makes it an ideal candidate to be deployed in every physician’s office and research laboratories.
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Lab Asia 31.2 April 2024
April 2024
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