IDO Pathway Products for Immunotherapy Drug Research

Amsbio offer a wide range of products for IDO pathway research, including cell lines, assay kits and active proteins to be used in IDO pathway research (IDO1, IDO2 and TDO genes).

Cancer cells use the indoleamine 2,3-dioxygenase (IDO) pathway to suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells. The IDO pathway is active in many tumours, providing a direct defence against T cell attack. The IDO pathway also is active in many antigen-presenting cells, resulting in peripheral tolerance to tumour-associated antigens.

Amsbio offers a high-performance range of Inhibitor Screening Assay Kits designed to measure IDO1, IDO2 and TDO enzyme inhibition. These simple-to-use kits come in convenient 96- and 384-well microplate formats with enough reaction solution and enzyme to perform a total of 100 reactions.

In addition, the company has assembled a selection of stable recombinant HEK293 cell lines for monitoring IDO1 and TDO pathway activity and screening for activators or inhibitors of IDO1 and TDO in a cellular context. For studying enzyme kinetics, substrate specificity and screening inhibitors, Amsbio also offers a comprehensive range of Human and Mouse IDO1, IDO2 and TPO His-tagged proteins.