Custom Design Services Offer Custom Optimised Antibody Panels

Custom Design Services (CDS) from Beckman Coulter, Inc provide researchers with single and multicolour custom-tailored conjugate configurations as well as purified antibodies. Beckman Coulter scientists, having extensive experience in the design and optimisation of multicolour reagent panels, work with a wide variety of proprietary or customer-supplied human and non-human antibodies. The company uses a comprehensive array of fluorochromes to create tests for an expansive range of targets.

Two- to 10-colour panels can be composed using fluorochromes to meet specific experimental requirements. Proprietary tandem dye technology provides optimal coupling efficiency and enhances signal-to-noise ratio, so that dyes can be used to detect low-density antigens without the loss of sensitivity. Antibodies may be lyophilised or supplied in a specified buffer solution.

Krome Orange, a novel violet-excited organic dye from Beckman Coulter, expands the range of available choices and dye sensitivity limits for violet lasers and facilitates the development of high-quality, multicolour panels. The panels are packaged in exclusive black vials to protect against photobleaching.

“From purification through delivery, the product is tested at each step and performance is characterised to assure that each lot meets the client’s precise specifications,” said William Godfrey, Beckman Coulter Product Development Center Group Manager. “Our conjugation processes are controlled to provide optimal coupling efficiency, and lower compensation requirements simplify instrument setup and give more flexibility in optimising multicolour combinations.”