Single-use Pharma Separator for Superior Cell Culture Processing

Research institutes and companies in the pharmaceutical industry from Europe, Asia and Europe have welcomed the kytero® Single-Use Pharma Separator from GEA following its launch in 2021. The system offers high separation efficiency, simple and gentle product handling and the elimination of costly cleaning procedures.

kytero® creates new ways for processing cell culture-based fermentations with a yield of 98% and more. This type of technology is in high demand for pilot plants, university laboratories, and small-scale production by biopharmaceutical manufacturers worldwide, as it relies on the well-established technology of disk separators. The use of filtration technology can thus be significantly reduced. The kytero® 500 was developed for a capacity of up to 150 l/h and is thus suitable for laboratories and small batches. For reliable scale-up, another model will follow in due course.

In centrifugation, unlike filtration, the separation of the medium is not achieved by filter media (filter plates and filter cloths), but by utilising the centrifugal force that occurs in conjunction with a disc stack for increased clarification efficiency. The mobile ‘Plug & Produce’ unit with a minimal footprint fits easily into any production room.

With the single-use separator, all product-contacting parts are replaced after use, preventing any cross-contamination without the need for cleaning and sterilisation. The frictionless drive system provides 100% biocontainment by eliminating the need for seals or mechanical bearings. Set-up and changeover time is minimal. No auxiliary equipment such as water, buffers, or tanks is required.

The noise level is very low at less than 69 dBA due to the newly developed breezeDrive® drive system. The temperature increase of the product, which is unavoidable during centrifugation, is minimal at less than two degrees. GEA kytero® inspires the pharmaceutical industry with its high separation efficiency, gentle product handling, easy and safe handling, and minimal set-up times. GEA provides test machines.

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