Characterisation of Nanomaterials in Commercial Products
Jun 19 2017 Comments 0
Postnova Analytics reports on how the inorganic analysis team within LGC has been using the AF2000 Field Flow Fractionation system coupled to Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to characterise nanomaterials in complex sample matrices for clinical, cosmetic and food use.
Dr Goenaga-Infante, Principal Scientist and Science Fellow at LGC, commented: “Over the last 15 years, Field Flow Fractionation (FFF) coupled to ICP-MS and other sizing detectors has proven itself a powerful tool for the characterisation of nanomaterials. For complex samples FFF seemed the ideal choice for matrix separation/sample fractionation, enabling us to achieve selective detection and characterisation of nanomaterials, that otherwise would have been hampered by the matrix components.”
Dr Goenaga-Infante added: “Having decided that FFF was the technique for us, we approached the two leading FFF manufacturers. We selected Postnova Analytics as our vendor of choice on the basis of their fast response to queries, scientific credibility and knowledgeable technical research assistance. The Postnova AF2000 system works robustly online when coupled with ICP-MS if a systematic approach is undertaken. We very much look forward to extending this collaboration into a partnership for life.”
A notable project where the FFF- ICP-MS has demonstrated its worth has been for the development of a methodology for the determination of number based concentration of silica nanoparticles with a diameter of approximately 80 nm in a complex serum sample. By itself, single particle ICP-MS failed to detect silica nanoparticles due to the high procedural blank for Si with the instrumentation available at the time. In addition, particle tracking analysis (PTA) failed to provide accurate number concentration data with a reasonable measurement uncertainty due to matrix interferences. By using flow FFF to separate the particles from the matrix with on-line PTA detection, LGC were able to accurately determine number-based concentration for silica nanoparticles of d < 100 nm in a complex biological matrix, with no requirement for chemical pre-treatment.
The Postnova AF2000 is a high performance Flow Field-Flow Fractionation (FFF) platform for separation of proteins, macromolecules and nanoparticles. Modular in design, the AF2000 incorporates the combined experience, expertise and technological advances from Postnova Analytics' nearly two decades of leadership in FFF. Incorporating a range of FFF modules in a single integrated system to provide universal separation, the AF2000 offers more flexibility, better performance and more robust results than any system before.
Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.
In this Issue Asian Guide to Scientific Instruments & Chemicals A Comprehensive Bibliography of Who’s Who in the Laboratory and Analytical Science Industry The following guide has been pro...
View all digital editions
Oct 19 2017 Loughborough, UK
Oct 23 2017 Moscow, Russia
Oct 31 2017 New York, USA
Nov 05 2017 Jeju Island, Korea
Nov 07 2017 BioCity Scotland