New Technology to Increase Process Understanding

B&W Tek has introduced the PTRam™, a self-calibrating portable Raman system for process development applications. The 19-inch rack-mountable system features a 785 nm laser with long-term stability together with high-throughput optics. PTRam operates with Vison software, Metrohm’s proven spectroscopic software for real-time analysis, which includes instrument control and data analysis. The PTRam is self-monitoring, with self-calibration and system performance validation tests automated in the Vision software to ensure the validity of each measurement. The system testing provides a complete instrumental status diagnosis, including Raman shift accuracy and photometric precision as set forth in USP <858>.

The PTRam can aid in product and process development efforts in the chemical, petrochemical and pharmaceutical industries through the ability to increase process understanding with information-rich Raman spectral data. Predictive quantitative models can be created, or trend monitoring can be performed to reduce calibration development time before full process definition. The PTRam is a valuable analytical tool for reaction monitoring and kinetic studies, blending and mixing, fermentation monitoring, solvent exchange, tablet coating monitoring, and other processes for real-time understanding of chemical and morphological changes as they occur. B&W Tek offers a full line of sampling probes and other accessories to optimise measurement for the systems being studied.

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