New Single Quadrupole Mass Spectrometer and Specialised Columns Designed to Deliver Reproducible and Robust Separations, Increase Analytical Accuracy

Thermo Fisher Scientific Inc has announced new technologies that are designed to allow analytical chemists to obtain high-resolution separations with outstanding sensitivity and reproducibility.

“Our customers want gain a deeper understanding of their samples,” said Mitch Kennedy, Vice President and General Manager, Life Sciences Business, Chromatography and Mass Spectrometry, Thermo Fisher. 

The new ISQ EC Single Quadrupole seamlessly integrates with an existing ion chromatography (IC) or high performance liquid chromatography (HPLC) system and provides excellent small molecule sensitivity and mass confirmation for users. The industry-leading Chromeleon Chromatography Data Software (CDS) platform has embedded ISQ EC MS instrument control, which enables users to minimise time spent on new mass spectrometry (MS) user training. The instrument also provides exceptional robustness, enabling users to analyse a range of simple and complex sample matrices.

The new range of Thermo Scientific MAbPac RP 1mm columns, which are designed to provide the resolution and ruggedness required for high-performance, reversed-phase chromatography characterisation of monoclonal antibodies, fragments, variants, antibody drug conjugates and proteins. With a 1mm inner diameter, the new columns provide sensitive analyses of very small sample volumes at low flow rates for direct injection into the LC-MS, thus streamlining workflows and achieving high sensitivity. Featuring a polymeric resin with an optimised pore size and thermal and pH stability, the new columns allow consistent and efficient separations with low carry-over.