Standardising Metabolomics to Provide Safety Guidelines
Aug 13 2017 Read 602 Times
A new initiative to accelerate the use of metabolomics technology to improve safety assessment of chemicals has been launched by The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). Embracing the study of small molecules in biochemical pathways which sustain life by generating energy, or through building larger molecules such as DNA, metabolomics has the potential to transform chemical risk assessment by providing a deeper view of the molecular events underpinning toxicity than is currently possible. However, because it is so new, scientists do not yet have standard procedures for applying metabolomics or reporting its findings, both of which are needed for chemical risk assessment.
The MEtabolomics standaRds Initiative in Toxicology (MERIT) announced by ECETOC brings together a team of international experts to address this problem by defining best practices and minimum reporting requirements when metabolomics is used in regulatory toxicology. It comprises partners from industry, government agencies, regulators and academia, from across Europe and the USA, including the US EPA, US FDA, EFSA, UK HSL, BASF HE, Syngenta, Unilever, Imperial College London, University of Birmingham, VU University Amsterdam and the Metabolomics Society Data Standards Task Group.
Alan Poole, Secretary General of ECETOC explains that “Omics has enjoyed a great deal of success in research. Nevertheless, the use of omics data in regulatory assessment has been hindered by the different approaches to the acquisition and processing of the data which can lead to different outcomes, even from identical studies. By focusing on gene expression and metabolic phenotyping, we can gather significant complementary information on regulatory processes and downstream function – both critical to understanding mechanisms of toxicity”.
Mark Viant, Professor of Metabolomics in the School of Biosciences and co-chair of the new group states said: “We need to address all the roadblocks to translating this highly effective technology of metabolomics into mechanism-based chemical safety science.”
Co-chair Dr Tim Ebbels Reader in Computational Bioinformatics at Imperical College and also co-chair, added: “The MERIT project is a critical step towards that goal.”
Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.
In This Edition Articles Chromatography - Visiting the 15th International Symposium - New Application Book Offers Expertise in GPC Analysis - Same Separation, Speedier Solution Mass S...
View all digital editions
Mar 22 2018 Istanbul, Turkey
Mar 23 2018 Beijing, China
Mar 27 2018 Guangzhou, China
Mar 28 2018 Lyon, France
Apr 02 2018 Suntec City, Singapore