Immobilised Chiral Columns Pave the Way to Novel Separations

High-speed analysis and reproducible results are paramount to efficient pharmaceutical research and development. CHIRALPAK® IA, IB and IC immobilised polysaccharide columns from Chiral Technologies allow chemists to choose from a large assortment of organic solvents. Use of CHIRALPAK immobilised columns helps to develop new separations and attain high levels of enantioselective recognition of chiral molecules.

The choice of mobile phase content in both enantioselective high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) has expanded dramatically to a greater variety of organic solvents due to the stability of the immobilised polysaccharide phases.

By using practically any organic solvent in conjunction with three immobilised chiral stationary phases (CSPs) - CHIRALPAK IA, IB or IC - chemists can maximise success rates in compound screening for identifying an effective separation of chiral molecules by enantioselective HPLC and SFC.

Additionally, immobilised column selectivities are complementary to those of coated polysaccharide-based CSPs, leading to a high degree of success in screening for a successful separation method using the available coated phases in a combination with CHIRALPAK IA, IB and IC.

The immobilised columns have been successfully employed in pharmaceutical research and development applications. The advent of CHIRALPAK IA, IB and IC offers enhanced compound solubility, greater column stability and novel column selectivity, all of which improve column lifetime.