• Can Gut Bacteria Slow Motor Neurone Disease?

Can Gut Bacteria Slow Motor Neurone Disease?

Aug 19 2019 Read 1023 Times

New evidence from Israel's Weizmann Institute suggests gut microbes play a major role in the development of neurological diseases such as Parkinson's, as well as conditions like motor neurone disease (MND). The new findings support evidence that's been building over the past decade and open exciting new treatment options.

Also known as amyotrophic lateral sclerosis (ALS), motor neurone disease occurs when specialised nerve cells in the brain and spinal cord malfunction. The condition worsens over time and is usually fatal, with death often caused by respiratory failure. It currently affects around 5000 British adults, with the Motor Neurone Disease Association stating a person's risk of developing MND is around one in 300.

The defensive role of the microbiome

The team was led by Professor Eran Elinav, principal immunology researcher at the Weizmann Institute. He prescribed broad-spectrum antibiotics to mice with a similar genetic condition to MND and saw the disease develop faster than mice in the control group. He also noted that after completing antibiotics courses, the mice raised in sterile environments had no opportunity to restock their healthy gut bacteria, which resulted in most of the group dying relatively quickly.

The findings were published in the journal Nature and revolutionise the way scientists view the gut-brain connection. They suggest that instead of triggering or accelerating neurological diseases, the gut ecosystem, also known as the microbiome, could act as an important defensive shield. Elinav muses that when key beneficial strains are absent it could significantly increase the risk of developing MND and other neurological diseases.

Tweaking microbe strains to slow the onset of MND

Elinav built on the findings by comparing the microbiomes of healthy mice with those of mice afflicted by early MND. The team pinpointed 11 gut microbe strains with notable differences and tested the defensive role of each by transplanting strains from healthy mice to those diagnosed with MND and treated with antibiotics. The team observed that after receiving akkermansia muciniphila, a strain of human intestinal mucin-degrading bacterium, mice lived longer and enjoyed a slower onset of MND. Elinav cites nicotinamide, a form of vitamin B3, as the most likely cause of the benefits.

While Elinav admits the research is "preliminary and observational" and not backed by human data, the findings mark an important step towards accelerating MND research and developing treatment options.

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Reader comments


Oct 04 2019

My mom ALS (amyotrophic lateral sclerosis) symptoms started out with a "foot drop" on her left foot. From there her left leg lost all muscle tone and all the entire left leg muscles was almost gone. Also her fingers and thumbs "contract" at times. Left arm is losing muscle tone too,she have been suffering from amyotrophic laterals sclerosis (ALS) disease for the last seven years and had constant pain which really get us worried, especially in her knees, the only treatment for this ALS (amyotrophic lateral sclerosis) is natural organic treatments honestly has the perfect herbal remedy to all the Motor Neuron Disease including ALS.


Mar 04 2020

My husband was diagnosed with MND ALS (amyotrophic lateral sclerosis) when he was 69 years old 6 years ago. The Rilutek (riluzole) did very little to help him. The medical team did even less. His decline was rapid and devastating. The psychological support from the medical center was non-existent and if it were not for and the sensitive cure of their herbal formula he would have been not been alive today,there was significant improvement in the first 4 weeks of usage that gave us hope that he will be alive,His doctor put him on riluzole, letting us know there was no cure until we gave try on total cure herbal supplement that cure him totally form this disease after 15 weeks of his usage.There is nothing positive about cure ALS condition except for their herbal treatment .


Apr 27 2020

I have been using taking BEST HEALTH HERBAL CENTRE ALS/MND HERBAL REMEDY for my ALS/MND for six weeks now. I use it once in the morning and at night mostly when I am finding it difficult to speak, raise my foot, and swallow. Since using this remedy, my need for Riluzole (Rilutek) has diminished dramatically. It also allows me to go for a walk, which was always difficult to do before using BEST HEALTH HERBAL CENTRE ALS/MND HERBAL REMEDY. For more information about the remedy

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