Nanoparticle Tracking Analysis used to develop Solutions for Cancer Diagnosis and Drug Delivery

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being applied in the development of future diagnostic and theranostic solutions for early diagnosis, drug delivery and treatment of cancer at the School of Medicine and CRANN, Trinity College Dublin, Ireland. 

Dr Adriele Prina-Mello is a Research Fellow at CRANN and a part-time lecturer at the School of Medicine, Trinity College Dublin. His research focuses on functional biomaterials, diagnostic devices, and multifunctional nanomaterials for theranostic solutions in the treatment of cancer. Fundamental in this work is the understanding of particle size, size distribution and of hydrodynamic response of nanoparticles dependent on their degree of aggregation. Additionally, being able to measure zeta potential and track particle behaviour in viscous or physiologically relevant media, informs the increasing characterisation demands of the nanomedicine community. Here pressure is on tools providers to offer the most comprehensive and low volume testing of sometimes very ‘expensive’ samples. 

Dr Prina-Mello described the Nanomedicine team goals: "Our main motivation for such levels of characterisation is determined by the potential use, applicability, and safety aspect linked to nanosize materials. This allows for further modification of the particle surface coating/moieties in order to get closer to the suitable candidate for diagnostic, monitoring and therapeutic application for nanomedicine and or biomedical research and also clinical translation. Furthermore, we also need characterisation information as basic preliminary understanding, in order to address wider experimental screening based on pharmaceutical standards, necessary to identify potential nanoparticle as lead carrier candidates for drug delivery of therapeutics". 

Continuing, he noted the benefits of using NanoSight's NTA instrumentation in complement to other characterisation techniques: "NanoSight allows for the identification of heterogeneity in particle size, poly-dispersity and counting with simultaneous zeta potential measurement. Furthermore, the use of small sample volumes compared to other techniques allows for cost effective, daily and routine characterisation."