Scaling up your biosynthesis? Check your lab and research chemicals

In biosynthesis workflows, consistency is everything. Whether producing oligonucleotides, peptides, proteins, or lipid nanoparticle (LNP) formulations, scientists depend on highly controlled processes to achieve reliable yields and reproducible results. 

However, maintaining that consistency is difficult as biologics and nucleic acid-based therapeutics projects move from research to larger-scale production. While risk-mitigation efforts are often focused on instrumentation or analytical methods, the purity and consistency of foundational inputs is a critical component labs can’t afford to overlook. 

Trace impurities have a major impact

Small variations in solvents and reagents affect synthesis formulation stability. Even trace amounts of contamination can influence reaction conditions and biological activity, alter product quality, reduce yields, and create variability between runs. 

The impact becomes larger and more difficult to control the further a program progresses. What begins as a minor inconsistency at the bench becomes a major obstacle during scale-up, disrupting performance and requiring time-intensive troubleshooting.

Adding to the challenge is the fact that these effects are often not immediately visible. What appears to be a small deviation during research can compound over time, creating downstream challenges that are far more costly and difficult to resolve. 

In an industry increasingly focused on accelerating development timelines, reducing variability at the source is a strategic advantage.

Here’s what to look for

Reproducibility can’t be engineered into a process later if variability is introduced at the start. Scientists need materials they can trust throughout the full lifecycle of development and production.

Burdick & Jackson BioSyn™ high-purity solvents and reagents from Solstice Advanced Materials are engineered to address these challenges in biosynthesis workflows. 

• Proven high-purity – Produced using controlled, closed-system manufacturing processes and dedicated equipment, Burdick & Jackson BioSyn products help minimise cross-contamination risk while delivering reproducible lot-to-lot consistency.
• Made for your exact needs – Solstice offers services for custom formulations, scalable packaging options, and customer-dedicated recycle container programs to help support operational efficiency while preserving product integrity throughout the process.
• State-of-the-art support – Behind every product is a team of technical experts who understand the challenges of biosynthesis scale-up. Their support helps scientists navigate complex workflows and maintain progress toward critical development milestones.

Future cures demand flawless chemistry

Biosynthesis is driving the next generation of therapeutics. Consistency is more than a quality requirement—it is the foundation for innovation. The quality of the lab and research chemicals entering a workflow is just as important as the technologies used to optimise it. When scientists can trust their materials, they can focus less on troubleshooting and more on advancing the future of medicine.

Learn how Burdick & Jackson BioSyn from Solstice Research Chemicals can help support scalable biosynthesis workflows for the science of tomorrow.

For informational purposes only; the content is not a guarantee of performance or results.

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