Mass Spectrometry & Spectroscopy

  • New High-resolution Mass Spectrometry-based Workflow Simplifies Biopharmaceutical Characterisation and Quality Control

New High-resolution Mass Spectrometry-based Workflow Simplifies Biopharmaceutical Characterisation and Quality Control

Jul 29 2019 Read 794 Times

The Thermo Scientific™ HR Multi-Attribute Method (MAM) meets the demand for a single, high-resolution mass spectrometry-based workflow designed to directly assess the product quality attributes of increasingly complex biotherapeutics. The workflow replaces the complicated sequence of lower-resolution methods that have previously prolonged characterisation timelines. Supported by the Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software, the HR MAM method simplifies and standardises biotherapeutic characterisation throughout the product pipeline, facilitating the transition of new drugs from initial research to development and manufacture.

With the launch of this new high-resolution mass spectrometry-based workflow, biopharmaceutical scientists are no longer restricted by the complex series of assays typically required for the characterisation and quality control of protein therapeutics.

The HR MAM provides biopharmaceutical scientists with:

  • A supported, comprehensive workflow from sample analysis to data processing, including new peak detection
  • Method development, SOP management and product quality attribute discovery capabilities through the integration of the Thermo Scientific™ BioPharma Finder software with Chromeleon CDS software
  • Flexible, 21-CFR part 11 compliant Chromeleon CDS software that supports the transition of development programs from early research to manufacturing and testing
  • High-resolution accurate mass capabilities and quality data to accurately identify peptides and post-translational modifications and allow reliable new peak detection using the Thermo Scientific™ Q Exactive™ Plus mass spectrometer

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