New Tribrid Mass Spectrometer with Improved Sensitivity Redefines the Limits of Protein and Small Molecule Quantitation and Characterisation

As the newest addition to the pioneering line of Thermo Scientific Orbitrap Tribrid mass spectrometers, the Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer is designed to expand performance in advanced proteomics, biopharma and metabolomics applications, including quantitation using isobaric tags, low level PTM analysis, data independent acquisition (DIA), and top down proteomics. The new instrument features enhanced sensitivity resulting in improved analyte detection, characterisation and quantitation, enabling scientists to perform more comprehensive sample analyses faster and with better accuracy than ever before.

To achieve proteome-wide coverage, the Orbitrap Fusion Lumos MS combines the versatility of a Tribrid system with the selectivity of Orbitrap technology, and the sensitivity and speed rivalling that of a triple quadrupole instrument. The new features include: brightest ion source - up to 5x improvement in limits of quantitation for peptides and small molecules; Segmented quadrupole mass filter powered by Advanced Quadrupole Technology – increase in selectivity of the analysis by improving isolation resolution, ion transmission and peak shape; Advanced Vacuum Technology – enhancement in detection limits by improving transmission of ions to the Orbitrap mass analyser; High-Definition Electron-Transfer Dissociation (ETD HD) – improvements in dynamic range and detection limits by performing ETD reaction on a larger precursor ion population, enabling greater sequence coverage in less time; ADAPT Technology – adjusts key parameters ‘on-the-fly’ without prior knowledge of sample amount, enabling maximum protein identifications from samples of unknown concentration in a single run and saving the user time and sample.