• Benchtop Tandem Quadrupole Mass Spectrometer
    The Xevo™ TQ Absolute system from Waters.

Mass Spectrometry & Spectroscopy

Benchtop Tandem Quadrupole Mass Spectrometer

Jun 16 2022

Waters’ Xevo™ TQ Absolute high-performance mass spectrometer is up to 15X more sensitive for quantifying negatively ionising compounds than its predecessor and is 45% smaller and uses up to 50% less electricity and gas supply than other high-performance tandem quadrupole mass spectrometers available on the market. The Xevo TQ Absolute is designed to help pharmaceutical, food and beverage, and environmental analytical laboratories meet regulations requiring trace-level quantitative mass spectrometry analyses for a broad set of applications.

For optimal performance, Waters pairs the Xevo TQ Absolute mass spectrometer with Waters’ ACQUITY™ Premier UPLC System with MaxPeak™ HPS technology which eliminates non-specific adsorption of compounds containing phosphate and/or carboxylate groups and improves their recovery.

Together, this integrated LC-MS/MS system is designed to drive the limits of quantitation to exceptionally low levels for many applications including: quantifying regulated impurities in drug products; performing oligonucleotide bioanalytical assays; measuring concentrations of endogenous metabolites in large cohort clinical studies; quantifying residues and contaminants in food and environmental samples; measuring low-level drugs and toxicants in physiological matrices; detecting trace-level leachables from food packaging.

The Xevo TQ Absolute incorporates thoughtful design features that enable consistent and reproducible analyses, allowing labs to maintain performance and uptime for longer periods in between routine cleaning and service intervals. This is achieved with new guidance on optimal probe positioning for both sensitivity and robustness and a source shield that helps minimise source contamination by the sample matrix or mobile phase salts.

The Xevo TQ Absolute is optimised for use with the waters_connect™ software platform and is also compatible with Waters MassLynx™ mass spectrometry software. For laboratories painstakingly reviewing the results from large numbers of samples, or those quantifying hundreds of small molecule components and contaminants in a single run, the MS Quan app on waters_connect and its unique Exception Focused Review (XFR) functionality, lets scientists review data in up to half the time it used to take them.

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