News & Views

  • Shionogi Partners with The AMR Centre for New Superbug Therapy

Shionogi Partners with The AMR Centre for New Superbug Therapy

Sep 11 2019 Read 1715 Times

The AMR Centre Ltd has announced a landmark agreement with the Japanese pharma company Shionogi to take forward its anti-virulence program, COT-143. The therapy is designed to help the body tackle Pseudomonas aeruginosa infections, a hard to treat drug-resistant pathogen recognised by the WHO as a critical threat to human health.

COT-143 is a novel humanised monoclonal antibody. It does not kill bacteria directly but targets an element that prevents the immune system from acting against the infection. COT-143 has already produced encouraging results in pre-clinical studies and regulatory toxicology tests in preparation for first-in-human clinical trials. The AMR Centre will further develop the program, taking it through a Good Manufacturing Practice clinical manufacturing campaign. It is in discussions about conducting phase one and phase two clinical trials at The Royal Liverpool University Hospital in 2020.

With the completion of this agreement, The AMR Centre, which is based at Alderley Park, Cheshire, will hold the exclusive worldwide right of research, development and manufacturing of COT-143. Shionogi, a global business with headquarters in Osaka, will share in revenues if the project progresses to market.

Dr Peter Jackson, executive director of the AMRC, said: “COT-143 is an advanced program that has produced very promising data against a dangerous pathogen that has a great deal of natural resistance to antibiotics. So we are very pleased to have reached this agreement and to be able to progress the high-quality science produced by Shionogi. This is also a milestone for the AMRC as it’s the first program we will get into clinic and tested in people. We have already had exploratory talks with the Royal Liverpool team about the clinical strategy for COT-143.

“Our dwindling supply of antibiotics continues to pose a grave threat to global health. Projects such as COT-143 are an example of excellent research struggling to progress in the context of market failure around the development of new antibiotics.  Our role is to bridge that gap and get these programs moving forward.”

Yoshinori Yamano, PhD, a chief scientific officer for infectious diseases, of Shionogi said: “We are pleased to collaborate with AMR Centre which has a function to promote clinical development of novel anti-infective agents by utilising various foundations and medical networks. By the collaboration with AMR Centre, we expect that it will realise efficient development of COT-143 which has demonstrated the potential to reduce tissue and cellular damage by the toxins released by this system, leading to the treatment of infection caused by Pseudomonas aeruginosa by using a variety of nonclinical in vitro and in vivo models. This collaboration, if successful, will enable us to move one step closer in realising a protecting people from the threat of infectious diseases.”

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment

Digital Edition

Lab Asia August 2020

August 2020

In This Edition Chromatography - Measurement of Pesticides in Cannabis sativa and Hemp Matrices - Biphenyl Modified Silica Stabilised by Bulky Substituents - Wettable Phase for Analytical a...

View all digital editions


SIAF Guangzhou - NEW DATES

Aug 11 2020 Guanghzou, China

IE Expo China 2020 - NEW DATES

Aug 13 2020 Shanghai, China

ACS National Meeting & Expo, Fall 2020

Aug 16 2020 San Francisco, CA, USA

Chemspec India 2020 - CANCELLED

Aug 19 2020 Mumbai, India

View all events