Obtaining accurate dissolution data during early-phase discovery/development is now possible using the pION µDiss ultra-small volume dissolution apparatus, available from Heath Scientific Co Ltd.
The µDiss is ideal for characterising intrinsic dissolution of powders and for polymorph screening where the active pharmaceutical ingredient is not available in large quantities. Using in situ fibre optic UV measurements in volumes as small as 2ml, the uDiss can generate detailed dissolution profiles in minutes. No removal of the sample during measurement is required. Up to six vessels can be studies simultaneously. Each of the six channels of the µDiss apparatus has a dedicated photodiode array detector for fast, whole spectrum UV data.
Other features include: a six-well stable-temperature aluminium block capable of holding 12mm or 24mm vials for 2-4ml and 5-20ml dissolution respectively; individually controlled mini-stirrers for reproducible results; digital RPM readout of stirring speed; a sturdy probe manifold to provide uniform height; an outfit for thermostatically controlled water bath circulation; and Indigo dissolution software that provides a simple, user-friendly interface which allows quick method development.
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