New kit enables detailed chromatin insights

EpiCypher® has unveiled its CUTANA® Fiber-seq Kit, designed to make cutting-edge single-molecule chromatin mapping accessible to researchers worldwide. This launch follows the company’s exclusive licensing of key Fiber-seq technology from the Altius Institute for Biomedical Sciences.

Fiber-seq is a breakthrough method that reveals how DNA and chromatin are organised and regulated at the single-molecule level. It simultaneously maps chromatin accessibility, DNA methylation, protein footprints, and genetic variation along individual DNA molecules, providing an unprecedented multiomic view of genome function.

The new kit includes all reagents needed to take samples from cells to purified DNA ready for library preparation and is compatible with PacBio and Oxford Nanopore Technologies sequencing platforms. Using EpiCypher’s exclusive Hia5 enzyme, a highly active adenine methyltransferase, researchers can achieve precise and reproducible chromatin labelling across the genome.

“This technology allows scientists to connect genetic variation to epigenetic regulation with a single-molecule view, unlocking insights critical for drug development and biomarker discovery,” said Martis Cowles, Chief Business Officer at EpiCypher.

By combining advanced chromatin biochemistry with high-accuracy long-read sequencing, Fiber-seq offers a powerful platform for uncovering the functional landscape of the genome. Researchers can now explore gene regulation, disease mechanisms, and drug response with greater resolution and confidence than ever before.

The Fiber-seq kit complements EpiCypher’s expanding CUTANA® platform, which also includes ultra-sensitive CUT&RUN and CUT&Tag assays, along with a comprehensive library of designer nucleosomes. Together, these tools empower researchers to tackle complex questions in drug discovery, genomics, and epigenetics.

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