Core-Shell Media and Axia™ Packing Technology for High-Performance Lab-Scale Purification Combined

Phenomenex Inc announces the availability of the Kinetex® Core-Shell media packed in Axia hardware for preparative HPLC and SFC in lab-scale purification. Kinetex 5-micron particles in four phases ¬– C18, XB-C18, Phenyl-Hexyl and PFP – are now offered in 21.2mm ID Axia packing. This marks the first time that core-shell media has been offered in the Phenomenex Axia preparative format, which delivers longer column lifetime, higher efficiencies, improved performance and high reproducibility, compared to conventionally packed columns for lab-scale prep chromatography.

Kinetex 5-micron core-shell media, introduced just a few months ago, is the largest particle in the family and delivers better performance than 5-micron fully porous offerings, with no increase in backpressure. In fact, the new 5-micron media provides 60 to 90% higher average efficiencies compared to the same size fully porous columns with little to no method development.

The Phenomenex patented Axia packing and hardware technology, introduced in 2005, eliminates the drawbacks of traditional slurry packing, delivering uniform bed density and dramatic performance advances.

“This announcement brings together two award-winning technologies from Phenomenex,” explained J.T. Presley, Brand Manager for Phenomenex. “Every Axia preparative column has been optimised for each packing media to improve column-to-column reproducibility and increase packing densities, resulting in higher efficiencies and prolonged column lifetime.”

Kinetex Core-Shell Technology in the Axia preparative format delivers a performance advantage to customers in pharmaceutical and natural products development, who can now use scalable core-shell solutions from analytical stage UHPLC or HPLC methods to purification.