Fast 3D light sheet imaging with standard sample carriers

Capturing fast biological processes in three dimensions remains a major challenge, particularly when working with delicate live samples. Many key cellular events occur in milliseconds, making it difficult to observe them in real time without compromising sample integrity.

Leica Microsystems has introduced the Viventis SCAPE light sheet microscope to address this gap, enabling rapid 3D imaging while using standard sample carriers. Built around patented SCAPE (Swept Confocally Aligned Planar Excitation) technology, the system is designed for high-speed volumetric imaging, allowing researchers to follow dynamic biological events as they unfold.

By combining fast acquisition with gentle imaging conditions, the platform allows scientists to observe complex processes in live cells and model systems without disrupting physiological states. This approach supports more accurate, real-time insight into biological function while maintaining sample viability.

The use of standard sample carriers simplifies experimental workflows and improves reproducibility, making it easier to compare results across experiments and conditions. This consistency, combined with increased throughput, helps researchers generate robust datasets more efficiently.

The Viventis SCAPE microscope was introduced at Focus on Microscopy 2026 and is now available globally.

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