Sharper, brighter dyes for spatial imaging

Biotium has expanded its Tyramide Signal Amplification (TSA) portfolio with TyraMax™ Amplification Dyes and Kits, designed for superior brightness, photostability, and buffer stability. The dyes deliver up to 100-fold higher detection sensitivity compared to conventional immunofluorescence, making them ideal for multiplex fluorescence and advanced spatial biology workflows, including tissue mapping and cyclic immunofluorescence (CycIF).

The TyraMax™ line offers the widest range of colours, from blue to near-infrared, allowing researchers to design complex multiplex panels with maximum flexibility. All dyes, including near-IR options, remain stable in amplification buffer for at least 24 hours, supporting automated staining workflows and reducing the risk of signal loss due to oxidation.

“Many spatial biology methods still rely on dyes that underperform in brightness or stability,” said Lori Roberts, PhD, Director of Bioscience at Biotium. “TyraMax™ dyes address these limitations, enabling scientists to build larger, more reliable multiplex panels for cutting-edge imaging applications.”

TyraMax™ dyes are available as standalone reagents, trial sizes, or ready-to-use multiplex sets such as 3-Plex and 5-Plex Amplification Dye Sets with DAPI. Compared to leading competitors, TyraMax™ provides brighter, more stable signals at a more accessible price point, giving researchers confidence to optimise complex panels and workflows.

With TyraMax™, Biotium empowers scientists to achieve higher sensitivity, sharper signals, and more consistent results in spatial biology, tissue mapping, and multiplex fluorescence imaging. The dyes and kits are available through Biotium and authorised distributors worldwide.

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