• Simultaneous Measurement of Cations and Anions

Chromatography

Simultaneous Measurement of Cations and Anions

Jul 21 2008

ESA Biosciences, Inc has announced a simple and reliable HPLC method for simultaneous measurement of cations and anions, using its
award-winning Corona CAD universal detector. Since positive ions and negative ions are key components of everything from pharmaceuticals to food and beverages to fine chemicals, analysis of these atoms and
molecules is a critical step in product development and QA/QC. The new Corona CAD method improves results for users: it is more efficient than traditional techniques, since it measures anions and cations in a single run, and it is also more accurate, reliable, and cost-effective. The traditional method for ion measurement uses dedicated, single-purpose ion chromatography systems, which must be run by highly skilled operators with specialised reagents under tightly controlled conditions.
In IC, conductivity detection is used with a suppressor to reduce the background signal.
Separate equipment (exchange columns and suppressors) is required to measure cations and anions. This can be cumbersome and time-consuming. The cost of analysis is high: the use of resources - both human and
instrument - is inefficient, and the quality of the data generated can lack the necessary accuracy and precision required.
Equally suited to the methods-development laboratory and the factory floor, ESA`s Corona CAD system reliably measures compounds, independent of molecular structure, to lownanogram levels. Charged Aerosol Detection
(CAD) is a robust HPLC detection technology that delivers advanced capabilities to every HPLC-user lab. Besides excellent sensitivity,
the Corona CAD shows consistent interanalyte response independent of chemical structure, enabling quantitation across a range that exceeds four orders of magnitude.
This breakthrough detector can effectively analyse a wide diversity of chemical structures and important classes of molecules - from small organic molecules, proteins and peptides, to ions, carbohydrates, lipids, and polymers. The Corona CAD makes methods development, validation, and transfer fast and easy for applications in many industries.

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