Lyza Series: FTIR Spectroscopy for Material Verification and Quantification

FTIR spectroscopy remains a trusted workhorse for rapid, non-destructive molecular analysis, particularly for raw-material identity testing in line with pharmacopeial requirements. The same approach is widely applied across food, chemical, and other material-focused industries, where fast verification with minimal sample preparation is essential. Increasingly, however, laboratories are using FTIR for more than identity testing alone, extending its role to quantitative analysis and broader material understanding.

With Anton Paar’s Lyza series FTIR spectrometers, these workflows are implemented as predefined methods that combine measurement, processing, and spectral analysis in a single routine. This structured approach supports consistent results across users and applications, while reducing the number of manual steps required in daily operation. This is reflected in typical application scenarios, where identity verification of pharmaceutical substances can be performed in pharmacopeia-aligned workflows via comparison with certified reference standards.

Beyond verification, the Lyza series can also be applied to quantitative analysis. As shown in a recent application example, acetaminophen quantification in a corn starch matrix can be performed via diffuse reflectance FTIR, demonstrating a straightforward approach to concentration determination with minimal sample preparation. Even at low concentration levels, reliable calibration can be achieved by correlating spectral changes with analyte content. 

Similar workflows can be applied to other sample types. For example, CBD quantification in oils can be carried out via ATR FTIR across defined concentration ranges. In these cases, characteristic absorption bands change systematically with increasing concentration, enabling the creation of linear calibration models directly within the integrated quantification workflow. This allows users to establish calibration models efficiently and apply them consistently across routine measurements, supporting reproducible results in day-to-day laboratory work. Across applications, the underlying principle remains the same – measurement, comparison or calibration, and result – while the sampling technique is adapted to the sample type and analytical objective.

Depending on the analytical question, FTIR can be applied for identity confirmation, concentration determination, or as part of a broader characterisation approach. Lyza series FTIR spectrometers provide a consistent framework for these tasks through guided workflows, library-based evaluation, and a modular cell concept that supports solids, liquids, and gases – enabling flexible switching between measurement techniques such as ATR, transmission, and diffuse reflectance. Anton Paar’s FTIR spectrometers are available in a fully integrated standalone configuration with smartphone-like touchscreen operation, as well as a PC-operated configuration that supports fully compliant workflows, and key optical components are covered by a 15-year warranty.

Laboratories that want to evaluate the workflow with their own samples can request a 70-day risk-free in-lab trial of the Lyza series.