• Free White Paper: Modernising Pharmaceutical Assay Testing

Laboratory Products

Free White Paper: Modernising Pharmaceutical Assay Testing

Aug 06 2021

Free white paper gives recommendations for converting manual into automated titration procedures.

Titration is an important analytical method that is widely used for pharmaceutical assay testing. However, many USP monographs still refer to manual visual endpoint titration methods. Such manual procedures are not only tedious to perform but also more prone to human error. A free white paper by Metrohm summarises the steps involved converting an existing manual titration procedure to semi-automated or automated titration procedures and gives three practical examples.

Traditionally, the reaction endpoint of a titration is detected visually adding a colour indicator to the titration solution. By contrast, modern titration uses a digital burette, the endpoint is detected by an electrochemical sensor, and the results are calculated by a digital titrator. This automatic procedure is faster, more accurate, and today’s stringent requirements regarding data integrity (ALCOA) and regulatory compliance are met with ease.

The present white paper addresses the following topics:

  • How to replace the colour indicator by a suitable sensor
  • How to optimise sample sizes
  • How to set the right titration parameters, depending on the kind of titration, titrant, and sensor
  • How to select the right stop volume for the titration in order to save chemicals

Download the white paper here.


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