Gravimetric Sample Preparation Can Reduce Errors

Preparation of samples and standards are common tasks in an analytical laboratory, but often time and labour-intensive. This sample preparation paper from Mettler Toledo explores 10 compelling reasons to say goodbye to inefficient and inaccurate sample preparation methods. Tedious manual steps pose significant risk of errors and variability, with the potential to cause out-of-specification results. A gravimetric approach offers a truly viable, cost-effective alternative to using volumetric flasks.

‘10 Reasons to Say Goodbye to Inaccurate Concentrations’ describes gravimetric sample preparation, an innovative alternative to a manual volumetric approach. The gravimetric method, described in United States Pharmacopeia (USP) Chapter <1251>, involves weighing the sample and the solvent to prepare a specific concentration. Accurate solutions can be prepared in less time, using less material, and generate significant cost savings and productivity enhancement.

The list of benefits is compelling, including improvements in data collection, labelling, and traceability, as well as accuracy. A key advantage is the ability to make up exactly the amount of solution required, rather than being constrained by discrete volumetric flask volumes, which helps to conserve expensive materials and reduce disposal costs. Another advantage is the ability to add an automatically calculated amount of solvent based on the actual weight of sample weighed, ensuring accurate concentrations every time. Analysts spend less time and effort adjusting solid weights to meet tolerances, further enhancing process ergonomics.

Read the ‘10 Reasons to Say Goodbye to Inaccurate Concentrations’ paper now to learn more about the benefits of gravimetric sample preparation.