New White Paper Explains How To Optimise Flow Chemistry

Mettler Toledo is pleased to announce that a new white paper entitled ‘Enhanced Development and Control of Continuous Processes: A Review of Modern Technologies’ is joining the company’s extensive collection of thought-leadership resources.

The new paper reviews flow chemistry’s revolutionary role in pharmaceutical and fine chemistry environments, including its ability to enhance product quality, increase yield, elucidate synthetic route and improve reaction safety, all while reducing cycle time, which is critical to reducing development costs and capturing market share in today’s competitive manufacturing arena.

The paper explores mid-infrared (IR) spectroscopy as a convenient and nondestructive method for real-time inline flow chemistry monitoring, because it allows real-time data-gathering on the formation of products and reactive intermediates. This instantaneous feedback on how changing a parameter such as flow rate or reaction temperature affects a reaction enables faster, safer and more cost-effective process optimisation.

The intensity of IR energy absorbed at a particular wavelength is defined by Beer’s law to be proportional to concentration, making it possible to track the relative concentration of individual reaction components using mid-IR-enabled technology. Employing this type of technology not only results in improved reaction understanding; it also allows researchers to overcome what used to be significant optimisation issues, such as making a controlled addition of reagent stoichiometries to a product stream using output data from a prior reaction stage when performing multi-step synthesis.

The paper describes specific instances where mid-IR technology and flow chemistry principles were applied to monitor product streams/dispersion effects in continuous flow reactors and allowed successful thirdstream reagent addition, helping to eliminate poor reaction control and the waste it produces.