Array Range Expanded Enabling Exon-Level CNV and LOH Detection
Jun 14 2016 Read 464 Times
Oxford Gene Technology (OGT), The Molecular Genetics Company, has announced the launch of its new CytoSure Constitutional v3 +LOH array for comprehensive genetic analysis of developmental delay disorders. Alongside the latest content for exon-level copy number variation (CNV) coverage, research-validated single nucleotide polymorphism (SNP) probes facilitate detection of loss of heterozygosity (LOH), enabling insightful and cost-effective analysis on a single array. The unique CNV content, already available on OGT’s CytoSure Constitutional v3 array, has received significant acclaim, with several major laboratories recently switching to this platform.
Utilising the latest discoveries from ClinGen and the Deciphering Developmental Disorders (DDD) study, OGT has incorporated every known region of the genome linked to developmental disorders to deliver the most up-to-date array platform for CNV detection currently available. The CytoSure Constitutional v3 array content covers 502 targeted genes, with high probe density across the most biologically relevant regions enabling the detection of single-exon aberrations. Now with the addition of SNP probes on the new CytoSure Constitutional v3 +LOH array, a broader range of copy-neutral genetic factors can be investigated on a single array, including LOH and uniparental disomy (UPD). Moreover, the SNP probe coverage also functions as an additional validation of CNVs, reducing the need to perform follow-up investigations.
Powerful data analysis and interpretation of these advanced arrays is also streamlined with OGT’s CytoSure Interpret Software, which is provided with each array alongside full on-site training. Innovative features enable automated data analysis, minimising user intervention and maximising both consistency and speed of interpretation.
The new CytoSure Constitutional v3 +LOH array builds on the existing success of the Constitutional v3 array, which has seen significant uptake in major clinical research laboratories across Europe and North America.
Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.
In this edition Articles - Detection of molecular markers in aquatic sediments by ion profi les obtained by GC/MS system - Fighting the Resistance: How Rapid Microbial ID with MALDI MS and A...
View all digital editions
Feb 20 2019 Mumbai, India
Feb 21 2019 New Delhi, India
Feb 25 2019 Moscow, Russia
Feb 26 2019 Guangzhou, China
Feb 27 2019 Berlin, Germany