Flow chemistry platform supports stereoselective synthesis advances

The Benaglia Group at the Università degli Studi di Milano has published seven peer-reviewed papers over two and a half years, demonstrating a series of stereoselective methodologies and pharmaceutical applications developed using the Syrris Asia Flow Chemistry System.

The work highlights how continuous flow chemistry can support process innovation across a range of applications, from chiral molecule synthesis to the production of biologically active compounds and fine chemicals.

Led by Professor Maurizio Benaglia, the group focuses on developing efficient and more sustainable approaches to stereoselective synthesis. To support this work, the team required a flexible and dependable flow chemistry platform capable of handling diverse reaction conditions. The Asia system was selected for its modular design and robust performance, enabling a smooth transition from batch processes to continuous flow methodologies.

Professor Maurizio Benaglia stated: 

"Asia gives us accurate control, reliability and reproducibility through continuous and precise flow rates."

Across the published studies, the researchers describe several novel stereoselective processes with both pharmaceutical and industrial relevance. Among the highlights is a telescoped synthesis of the antiepileptic drug levetiracetam using the Asia Photochemistry Reactor. The approach delivered improved productivity and enhanced space-time yield compared with traditional batch methods, underlining the advantages of continuous flow techniques.

Professor Maurizio Benaglia noted: 

"If you need a modular, reliable, and versatile flow chemistry platform, with a user-friendly control system, Asia is a very useful tool."

Further details of the group’s work and methodologies are available in the full case study.

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