Next-generation cryo-TEM  accelerates molecular structure research

Thermo Fisher Scientific has unveiled its most advanced cryo-transmission electron microscope (cryo-TEM) - the Krios™ 5 Cryo-TEM - designed to meet the growing demands of researchers investigating the structure and function of complex biological systems.

Building on the success of its predecessor, the Krios 5 delivers a step-change in cryo-EM performance, combining enhanced optics, streamlined workflows, and smart automation to significantly increase throughput and data quality. Capable of revealing the finest molecular details, the system supports both single particle analysis (SPA) and cryo-electron tomography (cryo-ET) applications.

The Krios 5 introduces a suite of improvements aimed at accelerating structure determination. AI-guided setup simplifies operation, while upgraded data acquisition tools increase image quality and consistency. With up to 25% greater throughput compared to earlier models, the Krios 5 allows researchers to extract more information in less time - bringing high-resolution 3D reconstructions of proteins and macromolecular complexes within closer reach.

For users focused on cryo-ET, a new vacuum capsule transfer system helps protect sensitive lamellae during sample handling, minimising ice contamination and preserving integrity throughout the imaging workflow.

High-fidelity visualisation of protein interactions, viral architecture, and cellular machinery is key to advancing drug development and therapeutic innovation. The Krios 5 supports this effort by making routine what was once considered cutting-edge - allowing researchers to push further into complex biological questions with confidence.

Trisha Rice, VP and General Manager of Life Sciences for Materials and Structural Analysis at Thermo Fisher Scientific, commented: “The Krios 5 Cryo-TEM delivers the automation, reliability, and performance that modern labs need to translate structural insights into scientific and therapeutic breakthroughs. It’s the result of close collaboration with the cryo-EM community and our ongoing mission to empower researchers with the tools to fight disease at the molecular level.”

The Krios 5 is equipped with an energy-efficient standby mode that reduces power usage without delaying experiments. It also carries the My Green Lab ACT ecolabel certification, aligning with lab sustainability goals.

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