Novasep Redefines Safety Properties of Reagent

Research scientists at Novasep, a leading supplier of synthetic molecules and biomolecules, recently discovered and characterised the explosive properties of the Togni reagent II and intermediates at the company’s Leverkusen site in Germany. Togni reagent II (1-(trifluoromethyl)-1,2-benziodoxol-3(1H)-one, 1) is a versatile reagent for the electrophilic introduction of trifluoromethyl groups. It is used in pharmaceutical manufacturing and also widely used in universities.

Authorised by the German Government to handle energetic materials and operate hazardous reactions from lab to thousands tons scale, Novasep conducted a Koenen test on a sample of Togni Reagent II prepared in their kilolab, in which the reagent was shown to be highly explosive. Another critical property of the Togni Reagent II clarified by the Novasep team is its fast combustion when ignited. The combustion factor was measured as BZ6, the same classification as black powder.

This discovery has resulted in a revised classification for handling and transportation of the Togni reagent II, which must now be approved by national competent authorities. Novasep has also informed companies known to market the compound, who will relay the safety measures required to handle the reagent.

“The work completed by Novasep regarding the Togni Reagent II will contribute to a more deliberate and responsible handling of the reagent used by so many research groups," said Professor Togni, professor of organometallic chemistry at the Laboratory of Inorganic Chemistry, ETH Zurich and inventor of the reagent.

The findings were published in the March edition of the journal Organic Process Research and Development.