Mass Spectrometry & Spectroscopy

  • Collaboration for Early Detection of Alzheimer’s Biomarkers Announced
    The product used for research (MALDI-TOF Mass Spectrometry ‘AXIMA Assurance’).

Collaboration for Early Detection of Alzheimer’s Biomarkers Announced

Jun 05 2020 Read 520 Times

Shimadzu introduces the collaboration with the Clinical Laboratory and Proteomics Platform of the CHU University Hospital of Montpellier, France. With the team of professors Sylvain Lehmann and Christophe Hirtz, they focus on MS based blood amyloid-beta analysis for early screening of amyloid-positive subjects. The cooperation plans to conduct a joint cohort study from the Memory Resources and Research Center (Professor Audrey Gabelle) to evaluate whether this simple blood analysis method enables early and accurate prediction of amyloid pathology in the brain with an easy-to-acquire blood sample.

Unlike conventional positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) testing methods, Shimadzu’s blood amyloid-beta analysis method is minimally invasive and suitable for large-scale deployment. It is a new-approach blood analysis capable of being used for the research of detecting abnormal amyloid-beta concentration which can be a marker for amyloid pathology in the brain.

These new blood-based biomarkers were discovered in 2014 by Shimadzu and the Japanese National Center for Geriatrics and Gerontology (NCGG). Although the screening analysis is Research Use Only and cannot diagnose Alzheimer’s disease, it is ideal for opening the door to new advancements in research, identifying suitable candidates for clinical trials and helping pharmaceutical company to test candidate drugs.

The blood analysis works using a combination of immunoprecipitation and MALDI-TOF mass spectrometry (IP-MS). This technique was first established by a team of scientists including Shimadzu’s Koichi Tanaka, who was awarded the Nobel Prize in Chemistry in 2002 for developing a method for mass spectrometric analysis of biological macromolecules.

The CHU of Montpellier is part of Shimadzu’s European Innovation Center (EUIC) program. The EUIC merges the cutting-edge analytical technologies of Shimadzu with game-changing topics and expertise in markets and science covered by opinion leaders, strategic thinkers and scientific experts in order to create new solutions for tomorrow.

More information online

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment





Digital Edition

Lab Asia June 2020

June 2020

In This Edition Articles Chromatography - What is Eluent Generation? - Automated online μSPE Clean-up for QuEChERS Approach to Pesticides Analysis - Simple and Seamless Routine Analysis...

View all digital editions

Events

Korea Lab 2020 - NEW DATES

Jul 27 2020 Kintex, South Korea

M&M 2020 - ONLINE EVENT

Aug 02 2020 Milwaukee, Wisconsin, USA

DXC 2020 - ONLINE EVENT

Aug 03 2020 Lombard, IL, USA

IE Expo China 2020 - NEW DATES

Aug 13 2020 Shanghai, China

ACS National Meeting & Expo, Fall 2020

Aug 16 2020 San Francisco, CA, USA

View all events