News & Views

  • Going Green for Tea Could be Healthy

Going Green for Tea Could be Healthy

Jun 23 2018 Read 355 Times

A compound found in green tea could be key to preventing heart attacks and strokes caused by Atherosclerosis. Scientists from Lancaster University and the University of Leeds currently studying the compound’s ability to reduce amyloid plaques in the brain in Alzheimer’s disease also found that it breaks up and dissolves potentially dangerous protein plaques found in the blood vessels.

Atherosclerosis is the build-up of fatty material inside arteries which can reduce the flow of blood to the heart and brain. In advanced stages of the condition, a protein called apolipoprotein A-1 (apoA-1) can form amyloid deposits, similar in structure to those associated with Alzheimer’s disease. These deposits build up within atherosclerotic plaques. Here, they increase the size of the plaques, further restricting blood flow and making the plaques less stable, increasing the risk of a heart attack or stroke.

Researchers found that epigallocatechin-3-gallate (EGCG), most commonly associated with green tea, binds to the amyloid fibres of apoA-1. This converts the fibres to smaller soluble molecules that are less likely to be damaging to blood vessels.

“The health benefits of green tea have been widely promoted and it has been known for some time that EGCG can alter the structures of amyloid plaques associated with Alzheimer’s disease,” said David Middleton, Professor in Chemistry at Lancaster University. “Our results show that this intriguing compound might also be effective against the types of plaques which can cause heart attacks and strokes.”

Now, the team are working on finding ways of introducing effective amounts of EGCG into the bloodstream without it being necessary to drink large and potentially harmful quantities of green tea. This could involve modifying the chemical structure of EGCG, making it easier to be absorbed from the stomach and more resistant to metabolism, or developing new methods to deliver the molecule to the plaques - such as via an injection.

“The findings of this round of studies are very encouraging. We now need to apply the best scientific techniques to find how we can take the molecular ECGC element from green tea, and turn it into a functioning tool to combat life-limiting health issues,” said Professor Sheena Radford, Director of the Astbury Centre for Structural Molecular Biology at the University of Leeds and co-author of the research.

The research was funded by the British Heart Foundation and also part-funded by BBSRC and published in the Journal of Biological Chemistry.

Read comments0

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.


Digital Edition

Lab Asia February 2019

February 2019

In this edition Articles - Detection of molecular markers in aquatic sediments by ion profi les obtained by GC/MS system - Fighting the Resistance: How Rapid Microbial ID with MALDI MS and A...

View all digital editions

Events

BioPharma World Expo 2019

Feb 20 2019 Mumbai, India

Medical Fair India 2019

Feb 21 2019 New Delhi, India

Biotech World

Feb 25 2019 Moscow, Russia

China Lab 2019

Feb 26 2019 Guangzhou, China

SmartLab Exchange

Feb 27 2019 Berlin, Germany

View all events