Research-grade Biosimilars for Biological Process Analysis
Aug 28 2021
How do biosimilars assist in drug discovery research?
Investigating the biological effects of a drug or doing proof of concept assay development, requires a source of the drug. Typically, it is difficult to obtain original pharmaceutical grade biotherapeutic drugs for research use, rather than a clinical application. Consequently, biological compounds almost identical to a reference biologic drug (biosimilars) that have been approved by governmental regulatory authorities for medical treatment are vital research tools.
To develop an effective biologic drug, it is important to synthesise a reference antibody. A reference antibody can greatly facilitate the downstream development of a new biologic drug and can help identify critical cell lines, reagents and performance characteristics. AMSBIO's new range of biosimilar antibodies for research use enable analysis of biological processes without the need to purchase expensive therapeutic-grade biologics.
One of the main challenges in analysing the impact of biosimilars is obtaining a validated positive control for in-situ analysis. For this task - FFPE cytosections of HEK293T cell pellet that over-express targeted proteins are available from AMSBIO. These cells are obtained by transfection of a sequenced verified cDNA clones transfected into HEK293T cells and the expression is verified by western blot and IHC analysis.
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