Researchers identify specific lab tests for early stage MS

Researchers in Israel say they have discovered which specific lab tests will allow them to identify early signs of multiple sclerosis (MS).

Standard neurological testing is used to examine and monitor the walking abilities and muscle strength of MS patients, but such methods are not effective at identifying deficits during the infancy of the disease.

A team at Tel Aviv University's Sackler Faculty of Medicine and the Multiple Sclerosis Centre in Sheba Medical Center, Tel-Hashomer, say they have discovered that specific laboratory tests for leg muscle endurance and gait are highly effective in identifying mobility deficits at the initial stage of MS.

They believe earlier identification of mobility problems would enable doctors to implement intervention programs that could make a big difference for those with MS.

Multiple sclerosis is a neurodegenerative disease which causes periodic attacks of neurologic symptoms such as limb weakness and mobility problems.

The researchers applied the lab tests to 52 patients in the early stage of MS and a control group of 28 healthy volunteers.

Using an isokinetic dynamometer, a special instrument for measuring lower limb muscle strength and endurance, the team measured lower limb muscle strength and endurance.

Participants were asked to try to bend or straighten their knee with maximum effort and to hold the position for 30 seconds.

On average, those in the early stages of MS were not able to maintain their strength — they demonstrated 40 per cent less endurance compared to the healthy control group.

"The downside of detecting such deficits using advanced instruments is offset by the positive potential of early intervention programs," said Dr Alon Kalron.

"If we find the abnormalities earlier, then we can start intervention programs when they have a chance to benefit the most."

Posted by Ben Evans