Need to Feed Programmes Campylobacter Pathogen  

Researchers at the Institute of Food Research on the Norwich Research Park have uncovered how the food-borne bacterial pathogen Campylobacter jejuni can change its behaviour according to the need for food or for finding a location suitable for respiration.

Campylobacter is the most common cause of bacterial food-borne illness in the UK, with more than 371,000 cases annually. When people get infected, the bacteria need to find their way from the infected source to the cells lining the gut, passing through thick layers of mucus.

Using a newly developed assay, the researchers found that Campylobacter balances the directions given by two different systems to either seek out more nutritious locations, or to find places where respiration is most efficient. Genetic tools were used to show that the system controlling swimming towards food overrides the other system, suggesting that the "need to feed" is the foremost concern for Campylobacter.

Unlike other food poisoning bugs, such as E. coli or Salmonella, Campylobacter has a whole range of systems that can detect different chemicals in the environment, and alter swimming behaviour accordingly

Dr Mark Reuter, the lead author of the study* said "we know that Campylobacter can swim, and that this is very important for causing disease, but aimless swimming isn't efficient. The bugs need to know where they want to go".

Discovering how these ‘Sat Nav’ systems help target the bugs to the site of infection may help prevent future disease, and may be relevant to other food-borne and gut-associated pathogens.

*Published in the journal PLOS ONE