News & Views

  • DPFS Scheme Supports Research into Prostate Cancer

DPFS Scheme Supports Research into Prostate Cancer

Mar 23 2020 Read 211 Times

Scientists at the University of Aberdeen have received almost £1.1 million from the Medical Research Council (MRC) to help fund a new treatment for advanced prostate cancer.

Under the Biomedical Catalyst: Developmental Pathway Funding Scheme (DPFS), Professor Iain McEwan, from the University’s Institute of Medical Sciences, is leading an interdisciplinary drug discovery project to explore new ways to attack treatment-resistant cancer.

Prostate cancer is the most common cancer in UK men with almost 50,000 new cases a year. It is estimated that by 2035 prostate cancer could kill 50 men a day.

Currently widely-used hormone treatments work by stopping male hormones like testosterone from feeding the cancer; testosterone binds to a protein inside a prostate cell, known as the androgen receptor and many prostate cancer drugs work by attaching to the androgen receptor, physically blocking hormones from being able to switch it on. However, in some men, the androgen receptor itself changes shape, so that it’s always switched on.

The Aberdeen team, in partnership with medicinal chemists led by Dr Craig Jamieson (University of Strathclyde) and collaboration with colleagues at Erasmus Medical Centre, Rotterdam, aim to develop novel small molecules that will switch off both normal and aberrant forms of the androgen receptor protein inside prostate cancer cells.

Professor Iain McEwan said: “Achieving this highly completive funding support from the MRC is a real boost to our research and was a real team effort, involving the close collaboration of researchers here in Aberdeen and Glasgow as well as Dr Ann Lewendon and colleagues in Research and Innovation.”

Reader comments

Do you like or dislike what you have read? Why not post a comment to tell others / the manufacturer and our Editor what you think. To leave comments please complete the form below. Providing the content is approved, your comment will be on screen in less than 24 hours. Leaving comments on product information and articles can assist with future editorial and article content. Post questions, thoughts or simply whether you like the content.

Post a Comment




Digital Edition

Labmate UK & Ireland April 2020

April 2020

In This Edition Articles - Export experts talk Corona Virus - Automated cell counting shouldn’t cost the earth Laboratory Products - Spectrophotometer Linearity Validation - Analysi...

View all digital editions

Events

Laborama 2020 - ONLINE EVENT

Jun 11 2020 Brussels, Belgium

HPLC 2020 - EVENT CANCELLED

Jun 20 2020 San Diego, CA, USA

MedtecLIVE - ONLINE EVENT

Jun 30 2020 Nuremberg, Germany

Korea Lab 2020 - NEW DATES

Jul 27 2020 Kintex, South Korea

IE Expo China 2020 - NEW DATES

Aug 13 2020 Shanghai, China

View all events